Edward J. Mascha, Ph.D.
Department of Quantitative Health Sciences /JJN3
Telephone: (216)445-7805
Fax: (216)444-8023
maschae@ccf.org

Positions:
Assistant Staff, Department of Quantitative Health Sciences and
Division of Anesthesiology, Critical Care Medicine, and Comprehensive Pain Management (joint)
The Cleveland Clinic Foundation, 2005-present

Senior/Lead/Research Associate Biostatistician, Biostatistics and Epidemiology
The Cleveland Clinic Foundation, 1994-2005

Alpha/Beta Statistical Team Leader, Biostatistics and Epidemiology
The Cleveland Clinic Foundation, 1999-2005

Biostatistician, Department of Biostatistics and Epidemiology
Henry Ford Health Sciences Center; Detroit, Michigan, 1990-1994

Education:
Ph.D., Biostatistics, Case Western Reserve University, Cleveland, OH, 2005
M.S., Biostatistics, CaseWestern Reserve University, Cleveland, OH, 1991
M.A., Theology, St. Mary Graduate School of Theology, Cleveland, OH
B.A., Philosophy, Borromeo College of Ohio, Wickliffe, OH

Key Interests:
Dr. Mascha currently leads Biostatistical collaboration for the Division of Anesthesiology, Critical Care Medicine and Comprehensive Pain Management. He joined the Clinic in 1994 after four years as a clinical trials and consulting statistician at Henry Ford Health Sciences Center in Detroit. He has co-authored numerous publications on a wide range of biomedical and statistical topics as well as led a team of collaborative Biostatisticians. His interests are in clinical trials, causal effects, reliability studies, longitudinal data analyses, correlated data problems, bootstrapping methods, and design of experiments. Current research involves assessing and estimating the heterogeneity of causal effects for binary, ordinal and survival outcomes using a potential outcome framework.

Selected Publications
Mascha E, Albert J. Estimating treatment effect heterogeneity for binary outcomes via dirichlet multinomial constraints. Biometrical Journal, December 2006 (published online Sep 14, 2006).

Mascha E, Albert J. Statistical properties of bound estimators on treatment effect heterogeneity for binary outcomes. Journal of Modern Applied Statistical Methods, 5(1), 181-193.

Albert J, Gadbury G, Mascha E. Assessing treatment heterogeneity in clinical trials with blocked binary outcomes. Biometrical Journal, 47 (2005) 5, 662-673.

Baker AR, Abreu EL, Mascha E, Derwin KA. Homotypic variation of canine flexor tendons: implications for the design of experimental studies in animal models. J Biomech 2004; 37 (7): 959-968.

Falcone T, Mascha E. The elusive diagnostic test for endometriosis. Fertil Steril. 2003 Oct;80(4):886-888. An editorial.

Schubert A, Przybelski RJ, Eidt JF, Lasky LC, Marks KE, Karafa M, Novick AC, O'Hara JF Jr, Saunders ME, Blue JW, Tetzlaff JE, Mascha E . Diaspirin-crosslinked hemoglobin reduces blood transfusion in noncardiac surgery: a multicenter, randomized, controlled, double-blinded trial. Anesth Analg. 2003 Aug;97 (2):323-32..

O'Hara PJ. Hertzer NR. Mascha EJ. Krajewski LP. Clair DG. Ouriel K. A prospective, randomized study of saphenous vein patching versus synthetic patching during carotid endarterectomy. Journal of Vascular Surgery. 35(2):324-32, 2002 .

Sprung J. Bourke DL. Grass J. Hammel J. Mascha E. Thomas P. Tubin I. Predicting the difficult neuraxial block: a prospective study.[comment]. Anesthesia & Analgesia. 89(2):384-9, 1999.

Tan M. Qu Y. Mascha E. Schubert A. A Bayesian hierarchical model for multi-level repeated ordinal data: analysis of oral practice examinations in a large anaesthesiology training programme. Statistics in Medicine. 18(15):1983-92, 1999.

Schubert A. Tetzlaff JE. Tan M. Ryckman JV. Mascha E. Consistency, inter-rater reliability, and validity of 441 consecutive mock oral examinations in anesthesiology: implications for use as a tool for assessment of residents. Anesthesiology. 91(1):288-98, 1999.

Stoller JK. Mascha EJ. Kester L. Haney D. Randomized controlled trial of physician-directed versus respiratory therapy consult service-directed respiratory care to adult non-ICU inpatients. American Journal of Respiratory & Critical Care Medicine. 158(4):1068-75, 1998.

The NINDS rt-PA Stroke Study Group (includes Edward Mascha). Tissue Plasminogen Activator for Acute Ischemic Stroke. New England Journal of Medicine 333:1581-1587, 1995.

Lyden P, Brott T, Tilley B, Welch KMA., Mascha E, Levine S, Haley E, Grotta J, Marler J, NINDSTPA Stroke Study Group. Improved Reliability of the NIH Stroke Scale Using Video Training. Stroke 25: 2220-2226, 1994.