Positions: Full staff, Quantitative Health Sciences, The Cleveland Clinic Foundation, 2005-present Staff, Biostatistics and Epidemiology, The Cleveland Clinic Foundation, 1991-2004 Education: PhD, Major: Statistics, Minors: Mathematics and Operation Research,Cornell University, 1985

Key Interests:
Dr. Greene works on NIH clinical trials coordinated by the Department of Quantitative Health Sciences and is interested in clinical trial design, epidemiological methods and multivariate data analysis.

Book Chapters:
Greene T, Lai J and Levey AS. Interpretation of Clinical Studies of Renal Disease. Chapter 40 in Immunologic Renal Disease, Neilson EG, and Couser WG (eds). Lippincoll-Raven Publishers, Philadelphia, Pennsylvania, pp 887-914 (1 st Edition: 1997, 2 nd Edition: 2001).

Greene T, Cheung A and Krediet R. Designing Clinical Trials in Dialysis, in Replacement of Renal Function by Dialysis, 5 th Edition. (In Press, 2002)

Selected Publications:
Greene T and Rayens W. Partially pooled covariance matrix estimation in discriminant analysis. Communications in Statistics: Theory and Methods. 18:3679-3702 (1989)

Greene T. The depiction of linear association by matroids. Journal of Computational Statistics and Data Analysis. 9:251-269 (1990)

Greene T. Descriptively sufficient subcollections of flats in matroids. Discrete Mathematics. 87:149-161 (1991)

Greene T and Ernhart CB. Dentine lead and intelligence prior to school entry: A statistical sensitivity analysis. Journal of Clinical Epidemiology. 46(4):323-339 (1993)

Levey AS, Greene T, Schluchter MD, Cleary PA, Teschan PE, Lorenz RA, Molitch ME, Mitch WE, Siebert C, Hall PM and Steffes MW for the Modification of Diet in Renal Disease Study Group and the Diabetes Control and Complications Trial Research Group. Glomerular filtration rate measurements in clinical trials. Journal of the American Society of Nephrology. 4:1159-1171 (1993)

Greene T , Lai J and Levey AS. Interpretation of Clinical Studies of Renal Disease. Chapter 40 in Immunologic Renal Diseases, Neilson EG and Couser WG (eds). Lippincoll-Raven Publishers, Philadelphia, Pennsylvania, pp 887-914 (1997)

Depner TA, Greene T, Gotch FA, Daugirdas JT, Keshaviah PK, Star RA and the Hemodialysis Study Group. Imprecision of the hemodialysis dose when measured directly from urea removal. Kidney International. 55:635-647 (1999)

Greene T , Depner TA and Daugirdas JT. Mathematical coupling and the relationship between Kt/V and nPCR. Seminars in Dialysis. 12:520-528, (1999)

Levey AS, Greene T, Beck GJ, Caggiula AW, Kusek JW, Hunsicker LG and Klahr S. Dietary protein restriction and the progression of chronic renal disease: What have all of the results of the MDRD Study shown? J Am Soc Nephrol. 10:2426-2439 (1999)

Daugirdas JT, Greene T, Depner TA, Gotch FA, Star RA and the Hemodialysis (HEMO) Study Group. Relation between apparent (single-pool) and true (double-pool) urea distribution volume in the HEMO Study. Kidney International. 56(5):1928-1933 (1999)

Levey AS, Bosch JP, Breyer-Lewis J, Greene T, Rogers N, Roth D for the MDRD Study Group. A more accurrate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation derived from the Modification of Diet in Renal Disease Study. Annals of Internal Medicine. 130:461-470 (1999)

Greene T , Beck G, Gassman J, Gotch FA, Kusek JW, Levey AS, Levin NW, Schulman G, Eknoyan G for the HEMO Study Group. Design and statistical issues of the Hemodialysis (HEMO) Study. Controlled Clinical Trials 21(5):502-525 (2000)

Schluchter MD, Greene T and Beck G. Analysis of change in the presence of informative censoring: Application to a longitudinal clinical trial of progressive renal disease. Statistics in Medicine 20: 989-1007 (2001 )

Greene T . A model for a proportional treatment effect on disease progression. Biometrics, 57: 354-360 (2001)

Wright J, Agodoa L, Greene T, Appel L, Bakris G, Charleston J, Cheek D, Douglas-Baltimore J, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Middleton J, Phillips R, Rostand S, Toto R for the AASK Study Group. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: Results from the AASK Trial. Journal of the American Medical Association. 288:2421-2431, 2002.

Daugirdas JT, Greene T, Depner TA, Leypoldt J, Gotch F, Schulman G and Star R for the HEMO Study Group. Factors affecting postdialysis rebound in serum urea concentration, including the rate of dialysis: Results from the HEMO Study. Journal of the American Society of Nephrology. 15: 194-203, 2004

Lewis J, Greene T, Appel L, Contreras G, Douglas J, Lash J, Toto R, Van Lente F, Wang X, Wright JT, Jr. A comparison of iothalamate-GFR and serum creatinine-based outcomes: acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension. Journal of the American Society of Nephrology 12:3175-3183, 2004

Vonesh E, Greene T, Schluchter M. Shared Parameter Models for the Joint Analysis of Longitudinal Data and Event Times, Statistics in Medicine, In Press, 2005.